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Endocrine Abstracts

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ea0099rc8.1 | Rapid Communications 8: Thyroid | Part II | ECE2024

The role of preexisting diabetes mellitus on the risk for aggressive thyroid cancers

Paparodis Rodis , Bantouna Dimitra , Livadas Sarantis , Angelopoulos Nicholas , Androulakis Ioannis , Simeakis George , Zianni Dimitra , Perogamvros Ilias , Boniakos Anastasios , Rizoulis Andreas , Jaume Juan Carlos , Karvounis Evaggelos , Kapezanou Aikaterini , Askitis Dimitrios

Introduction: Multiple cancers have been described more commonly in patients with diabetes, and some exhibit increased aggressiveness of the tumor as well. This association has been debated with regard to thyroid cancer. With this work, we aim to clarify whether type 2 diabetes (DM2) or autoimmunity-related diabetes (type 1 diabetes+LADA=DM1) could coexist with thyroid cancers more aggressive as compared to those found in unaffected (non-DM) individuals....
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ea0099p155 | Thyroid | ECE2024

Low TPO-antibody titers appear to promote aggressive thyroid cancers tumorigenesis: analysis of a large multinational dataset

Paparodis Rodis , Karvounis Evaggelos , Kapezanou Aikaterini , Bantouna Dimitra , Livadas Sarantis , Simeakis George , Askitis Dimitrios , Androulakis Ioannis , Angelopoulos Nicholas , Zianni Dimitra , Perogamvros Ilias , Boniakos Anastasios , Rizoulis Andreas , Imam Shanawaz , Carlos Jaume Juan

Introduction: In the thyroid gland, humoral immunity manifests with thyroid peroxidase (TPO) antibodies. In our studies, when TPO concentrations increased, thyroid cancers of follicular origin (TCFO) tended to develop less frequently.1 Other studies, though, reported an opposite trend in less aggressive cancers. The present work was designed to characterize the differential role of TPO antibodies in aggressive forms of TCFO (AGG) as compared to non-aggressive (NAG) ...
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Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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